The Foundation of Brain Nutrient Replenishment

Ultracholine® is a synergistic stack of high quality neurotransmitters and ingredients that are proven to improve cognition, mood and replenish choline levels in a way that no other product has been able to achieve.

As with all Mind Nutrition products, Ultracholine® it designed to be very safe and remarkably well tolerated with very low incidence of side effects. We use only the highest quality nutrients, individually tested and entirely gluten free and vegetarian friendly; even our DHA is sourced from natural microalgae.

The Science

We combine powerful choline nutrients and synergists into a specially formulated product that uses a multi-faceted approach when it comes to maximizing acetylcholine production and efficiency. What this means is that every single nutrient in Ultracholine® formulated with synergy in mind.

There is a proven synergy between the compounds Docosahexaenoic acid (DHA), Uridine Monophosphate (UMP – an organic molecule found in RNA that carries ATP units within the cell) and a choline source (we use two highly bio-available choline sources in Ultracholine®).

Animal studies (and human user reports) show that this combination of ingredients causes a significant elevation in several important aspects of neuronal cell biology, and this serves as the first facet of optimization:

  • A significant increase in the synthesis of Phosphatidylcholine (PC), resulting in greater membrane permeability, membrane health and nutrient transport into and out of the neuron.
  • An increase in the ability of the neuron to form new dendrites and synapses. Since dendrites and synapses are one of the forms of connections between neurons, and each neuron has 10,000 dendrites, we can see that this equals a greater propensity for neuroplastic changes, which is the ‘holy grail’ of cognitive improvement.
  • Increased levels of Acetylcholine (ACh) which is the neurotransmitter involved in higher thought and personality.

Further to these proven changes, there may also be increases in dopamine levels in the brain, which should increase feelings of motivation and drive, but which may (in some users) lead to potentiation of certain stimulants. DHA by itself has been shown to improve mood and restore sleep patterns.

Please note that although uridine is found in RNA, RNA products that claim to be sources of uridine are deceiving you; RNA is destroyed in the intestine and no uridine is transferred to the body. Uridine Monophosphate is the only form or source of uridine that is bio-available.

The use of UMP can lead to depletion of Vitamin B12, which is why Ultracholine® contains suitable levels of B12. We also include Vitamin B6, since it is a vital cofactor in the creation of various neurotransmitters.

Our CDP Choline contains nutrients that promote acetylcholine while also stimulating dopamine receptor growth. UMP is converted to CDP Choline in the brain, which means both these compounds gently elevate an important neurotransmitter for faster thought processes and a clearer state of mind. Alpha GPC is known for very easily crossing the blood-brain barrier and therefore has a high absorption rate, again facilitating PC and other neurotransmitter synthesis. The addition of these exogenous choline sources and cofactors serves as the second facet of optimization.

The next ingredient in Ultracholine® is Huperzine A, an acetylcholinesterase inhibitor derived from plant material. By reversibly inhibiting the enzyme that breaks down Acetylcholine (ACh) we can increase both the level and the duration of ACh within the synaptic cleft leading to greater signalling potential.

Use of Huperzine A (or other reversible acetylcholinesterase inhibitors) may increase the chance of lucid dreaming as well as slightly increasing the force of muscle contractions, due to greater ACh levels at the motor end plate. This is the third facet of balancing ACh levels.

Finally, Ultracholine® utilizes a natural, vegetarian friendly source of DHA which, when combined with UMP, can have an anxiolytic effect and therefore improve mood and reduce anxiety and its effects on the brain. DHA is also a primary structural component of the brain that modulates or controls the transport of choline, among many other functions.

In summary, we have designed Ultracholine® to be the only nootropic formula directly focused on replenishing and nourishing the vital neurotransmitters, vitamins and cofactors associated with optimal and elevated brain function.